With cannabinoids everything is a matter of patience and restraint. Right now, it is impossible to recommend an exact dosage by disease. Nevertheless, there are methods to help you find the right posology, adapted to your needs.
Towards an individual dosage
Contrary to traditional medications, cannabis is made of hundreds of molecules, and added to this your unique metabolism and the objectives you are trying to achieve, an individual dosage is adapted to each of us.
The scope of cannabinoids application is broad, it is used as a preventive medicine, to treat every day diseases but also to treat severe illnesses. In that respect, dosage can vary according to your needs and symptom intensity.
The example of a protocol to follow
The standard recommendations are between 0.2 and 10 mg CBD/kilo/day. This opens a wide range of possibilities; however, we have some advice to share with you:
Always start with a low dosage, 2 mg/day is a minimum, below this dosage it is not significant.
Increase your dosage gradually every 4/5 days, until you find your « therapeutic window » that is the moment where you see improvement. The improvement may not target yet at that stage the symptoms you want to get rid of but informs you that you are entering your « therapeutic window » by improving your sleep, mood, skin condition and so on.
As soon as you find your therapeutic window, stay on your actual dosage and maintain it for 3 /4 weeks.
If at the end of those 3 / 4 weeks you feel even more improvement, increase your dosage gradually for the following 3 / 4 weeks and so on as long as you feel positive effects.
Be aware of the biphasic effect of cannabinoids. Indeed, less can also mean better, so do not hesitate to come back to a previous and smaller dosage if you feel there is no more improvement or even if your state of health decreases.
Ingested cannabinoids should be taken during the meal.
Some precautions to take:
Although lethal dosage for CBD does not exist and that it is non-psychoactive, it should not be considered harmless.
Even if they are rare, some allergies can appear. This is why it is important to start with small doses, in order to see how your body reacts.
Cannabinoids intake can cause a lower blood pressure, if you are already taking some medication for your low-pressure state, you might have to reduce it to avoid this problem.
Another side effect stated by users is sleepiness, not always an undesirable effect!
Interaction with other drugs to consider:
Cannabinoids like CBD can inhibit the hepatic metabolism of pharmaceutical products. If you take some high dose of CBD, it can temporarily neutralize the enzyme activity in the liver and thus modify the way medication operates on your metabolism. There are still limited studies about this phenomenon, but it should be taken into account.
Here is a short list of medication which we know are sensitive to interactions with CBD:
Acid inhibitor Pantoprazol
Antiepileptic Clobazam (Frisium)
Acid inhibitor Omeprazol
Neuroleptics Risperidon (Risperdal)
For that reason, it is important to keep at least 2 hours between CBD and drugs.
Always inform your doctor about your intake of CBD, whether or not he is open to this method, he should be informed.
- Safety and side effects of cannabidiol, a Cannabis sativa constituent (2011)
- Dr Franjo Grotenhermen « Chanvre en médecine – redécouverte d’une plante médicinale ». Guide pratique des applications thérapeutiques du Cannabis, du THC et du CBD.
- MAMAKA – Intervention Jacqueline Poitras à la conférence de l’UCFM I Care, 20 octobre 2017.
- UFCM – Modes d’administration de produits à base de cannabis
- John Hicks – (biphasic effect)
- Biphasic Effects of cannabinoids in anxiety responses: CB1 and GABAb receptors in the balance of GABAergic and glutamatergic neurotransmission